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KMID : 0816120000030010098
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2000 Volume.3 No. 1 p.98 ~ p.104
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A Case of Clostridium difficile Pseudomembranous Colitis
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Seo Jung-Ho
Chung Ki-Sup
Lee Jong-Won
Lee Chang-Han
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Abstract
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Pseudomembranous colitis, thought to be uncommon in children, is a bacterial,
toxin-mediated inflammatory process resulting in acute or chronic diarrhea and is
characterized by colonic pseudomembranes. It is mediated by toxins produced by
Clostridium difficile and is increasingly recognized in pediatric population. Diagnosis is
based on positive culture of C. difficile in selective media and positive test of C. difficile
toxin. Oral metronidazole or vancomycin are the main treatment options but avoidance of
further antibiotics should also be encouraged where possible. We have experienced a
case of pseudomembranous colitis in a 4-year-old female presented with septic shock
and colitis. This case was diagnosed with positive test of C. difficile toxin B and
confirmed by isolation of the organism on cultire in selective media. Symptoms have
been ameliorated by discontinuation of antibiotics and administration of metronidazole
and oral vancomycin, and ICU care.
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KEYWORD
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Pseudomembranous colitis, Clostidium difficile, Toxin A, Toxin B Vancomycin, Metronidazole,
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